Non-invasive Monitoring of Drugs Bioavailability by Tissue Impedance Measurement
Topical administration and transdermal delivery are advantageous in comparison with systemic administration routes because complications such as first-pass metabolism, toxicity, and side effects are attenuated for the patient. Their effectiveness is evaluated by numerous studies in the laboratory. However, performance outside of a laboratory, in the context of daily clinical application, is less investigated.
After an introduction on EIS for prosthesis osseointegration diagnostics in audiology and Artificial Intelligence for model definition in EIS, this tutorial presents a measurement method (in aesthetic medicine) to evaluate the amount of a substance delivered into a tissue. A second measurement method for indirectly assessing insulin bioavailability is discussed. The leakage of a given amount of insulin produces a corresponding variation in the measured equivalent impedance in the administration volume.
Pasquale Arpaia took Master Degree and PhD in Electrical Engineering at University of Napoli Federico II (Italy), where he is full professor of Instrumentation and Measurements. He is Head of the Instrumentation and Measurement for Particle Accelerators Laboratory (IMPALab) and the Augmented Reality for Health Monitoring Laboratory (ARHeMlab). He is Team Leader at European Organization for Nuclear Research (CERN). He is Deputy Chairman of the Interdepartmental Center for Research on Management and Innovation of Health (CIRMIS), Head of the Hi-Tech Academic FabLab Unina DIETI and Chairman of the Stage Project of the University Federico II. He was also professor at University of Sannio, associate at Institutes of Engines and Biomedical Engineering of CNR, and now of INFN Section of Naples. His main research interests include instrumentation and measurement for magnets, advanced materials, beam, superconductors, power converters. and cryogenics of particle accelerators, biomedical instrumentation, Augmented Reality, Brain Computer Interfaces, evolutionary diagnostics, distributed measurement systems, ADC modelling and testing. In these fields, he published 3 books, and about 300 scientific papers in journals and national and international conference proceedings. His PhD students were awarded in 2006, 2010, and 2020 at IEEE I2MTC, as well as in 2016 and 2012, 2018 at IMEKO TC-10 and World Conferences, respectively.
Nicola Moccaldi received the M.S. degree in communication science from the Faculty of Arts and Philosophy, University of Salerno, Fisciano, Italy, in 1999, and the M.Sc. degree in electronic engineering from the University of Naples Federico II, Naples, Italy, in 2018. Since 1999, he has done numerous professional assignments in the social and health sector policies including planning and implementation of corporate communication, coordination of complex services, design, and the evaluation of services, on behalf of several nonprofit organizations and government agencies. Since 2015, he has been a Researcher in electronic engineering applied to biomedical field with Innovum S.R.L., Naples. He is currently a Research Associate with ARHeMLab - DIETI, University of Naples Federico II. His current research interests include biomedical instrumentation and measurement. He has authored or coauthored several scientific papers in journals and national and international conference proceedings in this field.
Audience: Young Professionals, Professionals in I&M, Researchers, Students
Publication Year: 2021