Fiberless Optoelectrodes for Selective Optical Neuromodulation at Cellular Resolution
This talk will review the evolution of Michigan neural probe technologies toward scaling up the number of recording sites, enhancing the recording reliability, and introducing multi-modalities in neural interface including optogenetics. Modular system integration and compact 3D packaging approaches have been explored to realize high-density neural probe arrays for recording of more than 1,000 channels simultaneously. In order to obtain optical stimulation capability, optical waveguides were monolithically integrated on the silicon substrate to bring light to the probe shank tips. Excitation and inhibition of neural activities could be successfully validated by switching the wavelengths delivered to the distal end of the waveguide. For scaling of the number of stimulation sites, multiple micro-LEDs were directly integrated on the probe shank to achieve high spatial temporal modulation of neural circuits. Independent control of distinct cells was demonstrated ~50 μm apart and of differential somato-dendritic compartments of single neurons in the CA1 pyramidal layer of anesthetized and freely-moving mice.
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Instructor
Euisik Yoon, Ph.D.
Euisik Yoon received the B.S. and M.S. degrees in electronics engineering from Seoul National University in 1982 and 1984, respectively, and the Ph.D. degree in electrical engineering from the University of Michigan, Ann Arbor, in 1990. From 1990 to 1994 he worked for the Fairchild Research Center of the National Semiconductor Corp. in Santa Clara, CA, where he engaged in researching deep submicron CMOS integration and advanced gate dielectrics. From 1994 to 1996 he was a Member of the Technical Staff at Silicon Graphics Inc. in Mountain View, CA, where he worked on the design of the MIPS microprocessor R4300i and the RCP 3-D graphic coprocessor. He took faculty positions in the Department of Electrical Engineering at Korea Advanced Institute of Science and Technology (KAIST) in Daejon, Korea (1996-2005) and in the Department of Electrical and Computer Engineering at the University of Minnesota, Minneapolis, MN (2005-2008), respectively. During the academic year of 2000- 2001, he was a Visiting Faculty at Agilent Laboratory, Palo Alto, CA. In 2008, he joined the Department of Electrical Engineering and Computer Science at the University of Michigan, Ann Arbor, MI, where he is a Professor and the Director of NSF International Program for the Advancement of Neurotechnology. He served as the Director of Lurie Nanofabrication Facility at the University of Michigan from 2011 to 2016. His research interests are in MEMS, integrated microsystems, and VLSI circuit design.
Dr. Yoon has served on various Technical Program Committees including the Microprocesses and Nanotechnology Conference (1998), the International Sensor Conference (2001), the IEEE Asia-Pacific Conference on Advanced System Integrated Circuits (2001-2002), the International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers) (2003, 2005), the IEEE International Electron Device Meeting (2006-2008) and the IEEE International Conference on Micro Electro Mechanical Systems (2006, 2009-2010). He also served on the IEEE International Solid-State Circuit Conference program committee (2003-2007) and was a general chair of International Symposium on Bio Micro & Nanosystems (2005). Currently, he serves as an associate editor for IEEE Solid-State Circuits Letters.
Publication Year: 2019